ICREA Academia Awards are given for a period of five years in recognition of an excellent scientific trajectory of university professors. Awardees receive funds over this period to support their lines of research,e ICRE teaching activities and allow awardee to focus on research activity.
The Integrase Strand Transfer Inhibitor (INSTI) antiretrovirals are among the last generation drugs to treat HIV-infected patients. Recent data indicate that these patients show abnormally increased adiposity after treatment. Thus, the HIV infection and global obesity epidemics meet to confer to HIV patients increased metabolic and cardiovascular comorbidities.The coordinated research projects will assess the molecular and cellular basis of such phenomenon and will identify potential targets of preventive intervention.
That system, in which bradykinin is a main actor, has been traditionally associated with the physiology of the renal and cardiovascular systems and processes of inflammation and pain. Our study, led by Dr.M.Peyrou, Juan de la Cierva researcher at our lab, reports that the kallikrein-kinin system acts as mechanism of molecular self-control of brown and beige adipose tissue thermogenic activation, and could help prevent the harmful effects of excessive activation of brown adipose tissue occurring in some pathological conditions such as cachexia or recovery from severe burns.The full article is accessible at: https://rdcu.be/b3Ud4
Dr. Cairó received the award for the presentation "Parkin controls brown adipose tissue adaptive plasticity in response to thermal adaptations and obesogenic diet"
A project on hepatocarcinogenesis and metabolic lipotoxity, led by Francesc
Villarroya, has been one of the initiatives selected by the AECC, in the category of Ideas Semilla 2019. F. Villarroya was in charge of representing the project in the commemorative act that the AECC held on September 24, in the Reina Sofía Museum in Madrid, on the occasion of World Research Day in Cancer (World Cancer Research Day).
In this edition, the AECC Scientific Foundation Research programs awarded 171 projects worth about 21 million euros, which integrate from great innovative and disruptive ideas to projects financed in a coordinated manner with large European foundations. Our focus is to investigate whether brown fat activation could be protective against liver cancer, as preliminary studies in our laboratory suggest.
