As the body ages, the activity of brown adipose tissue declines, contributing to an increased risk of cardiometabolic disease. A study led by Joan Villarroya and colleagues in our research team has identified chaperone-mediated autophagy as a key molecular mechanism underlying the decline in brown adipose tissue activity with aging. This discovery opens new avenues for developing strategies to enhance the function of this tissue and help prevent chronic metabolic and cardiovascular diseases in an aging population. The study was published in Science Advances (DOI: 10.1126/sciadv.ady0415) and was carried out in collaboration with the team of Ana María Cuervo at Albert Einstein College of Medicine in New York.