Tirzepatide is one of the drugs that has revolutionized the treatment of obesity and other conditions such as diabetes in recent years. Despite its clinical success, its precise molecular and cellular mechanisms are still not fully understood. Our study in mice, led by Dr Marion Peyrou, shows that the drug has a direct impact on improving metabolism by activating brown adipose tissue. Our results, published in the February 2026 issue of Biomedicine and Pharmacotherapy (DOI: 10.1016/j.biopha.2026.119057) help to better understand the mechanisms of action of tirzepatide and open up new avenues for developing more comprehensive treatments for obesity and other metabolic diseases.