Category Archives: Uncategorized

18
Oct
Date 18/10/2022
Categories Uncategorized

The NAM-AIDS international platform quotes our study on the effects of antiretroviral drugs in relation to adipose accretion in people leaving with HIV.


Increased adiposity is a current concern in people living with HIV treated with the last-generation antiretroviral drugs of the integrase inhibitor family. The platform NAM-AIDSMAP, devoted to provision of independent, accurate & accessible information about HIV, highlights our findings recently published in Life Sciences (doi: 10.1016/j.lfs.2022.120948). We showed that the integrase inhibitor dolutegravir suppresses the production of adiponectin, a chemical secreted by fat tissue that regulates insulin sensitivity, which provides further evidence that dolutegravir can have direct effects on the human cells that store fat (see https://www.aidsmap.com/news/oct-2022/dolutegravir-has-direct-effects-fat-cells).






Author tamweb
16
Oct
Date 16/10/2022
Categories Uncategorized

Our research team contribute to the EMBO workshop “Energy balance in metabolic disorders” in Málaga.


Francesc Villarroya, as invited speaker, Tania Quesada, through a selected communication, and Moisès Castellà through a poster communication, presented our current research on inter-organ singaling and molecular actors involved in metabolism and adipose tissue thermogenic plasticity at the EMBO meeting held in Málaga last 3 to 6 October.






Author tamweb
01
Apr
Date 01/04/2021
Categories Uncategorized

Our research team participates in a study identifying betaine as a key component of breast milk capable of protecting against obesity in children.

In line with our affiliation to Institut de Recerca Sant Joan de Déu (IRSJD), we participated in a study published recently in Science Translational Medicine (DOI: 10.1126/scitranslmed.abb0322), the prestigious journal from the Science group. This research, led by Dr. Carles Lerin at IRSJD, identified an inverse relationship between maternal breast milk betaine content and infant growth, and it was demonstrated that  maternal betaine supplementation during lactation induced a transient increase in offspring intestinal Akkermansia abundance, and reduced early weight gain. Furthermore, it was shown that maternal betaine supplementation decreased adiposity and improved glucose metabolism throughout adulthood, demonstrating a link between breast milk betaine content and long-term metabolic health. Our participation in this study is a follow up of  our long standing research on the molecular basis of the healthy properties of breastfeeding.
Author tamweb
29
Mar
Date 29/03/2021
Categories Uncategorized

Francesc Villarroya, among the top 2% worldwide scientists according to a PLOS Biology study.

A recent article  (https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000918) published in PLOS Biology, presents a list of the 2% of scientists worldwide that lead different disciplines. This ranking has been conducted with the information provided by the Scopus database. Francesc Villarroya appears as one of these top 2% influential researchers in field of Endocrinology and Metabolism.
Author tamweb
15
Feb
Date 15/02/2021
Categories Uncategorized

The PhD student at our lab Albert Mestres-Arenas wins the award to the best graduation thesis document writen in Catalan language.

Albert Mestres Arenas, PhD student at our team, has been awarded by "Comissió de dinamització Lingüística de la Facultat de Biologia UB" with the prize to the best graduation thesis document written in Catalan (academic year 2019-20) for his work “Caracterització fenotípica del teixit adipós perivascular aòrtic i estudi comparatiu amb altres dipòsits adiposos”, developed at our laboratory. Congratulations!
Author tamweb
24
Nov
Date 24/11/2020
Categories Uncategorized

The “Institut de Recerca Sant Joan de Déu” is appointed as a CERCA research center.

The "Institut de Recerca Sant Joan de Déu" (IRSJD) has been recognized by the Board of Trustees of the Institution of the Research Centers of Catalonia (CERCA) as a CERCA center. This  implies the recognition of the frontier biomedical research developed at IRSJD and oriented to the improvement of quality of life in children and adults. The CERCA recognition implies entering the Catalan research structure, as a top quality research center showing efficient management, and will allow access to additional funds to develop scientific activities.

Our research team has been part of IRSJD for a few years, which has enhanced our translational research in metabolism and endocrinology in collaboration with clinics at Sant Joan de Déu hospital. Examples of our translational research in pediatrics follow:


Reduced circulating levels of chemokine CXCL14 in adolescent girls with polycystic ovary syndrome: normalization after insulin sensitization.
García-Beltran C, Cereijo R, Quesada-López T, Malpique R, López-Bermejo A, de Zegher F, Ibáñez L, Villarroya F.
BMJ Open Diabetes Res Care. 2020 Feb;8(1):e001035.

Circulating growth-and-differentiation factor-15 in early life: relation to prenatal and postnatal growth and adiposity measurements.
Díaz M, Campderrós L, Guimaraes MP, López-Bermejo A, de Zegher F, Villarroya F, Ibáñez L.
Pediatr Res. 2020 Apr;87(5):897-902.

Growth Differentiation Factor 15 is a potential biomarker of therapeutic response for TK2 deficient myopathy.
Dominguez-Gonzalez C, Badosa C, Madruga-Garrido M, Martí I, Paradas C, Ortez C, Diaz-Manera J, Berardo A, Alonso-Pérez J, Trifunov S, Cuadras D, Kalko SG, Blázquez-Bermejo C, Cámara Y, Martí R, Mavillard F, Martin MA, Montoya J, Ruiz-Pesini E, Villarroya J, Montero R, Villarroya F, Artuch R, Hirano M, Nascimento A, Jimenez-Mallebrera C.
Sci Rep. 2020 Jun 22;10(1):10111.


Brown adipose tissue in prepubertal children: associations with sex, birthweight, and metabolic profile.
Malpique R, Gallego-Escuredo JM, Sebastiani G, Villarroya J, López-Bermejo A, de Zegher F, Villarroya F, Ibáñez L.
Int J Obes (Lond). 2019 Feb;43(2):384-391.


Author tamweb
31
Jul
Date 31/07/2020
Categories Uncategorized

The Instituto de Salud Carlos III funds a research project led by Dr. Marta Giralt, in coordination with Dr. Pere Domingo from Hospital de la Santa Creu i Sant Pau, to investigate the abnormal body weight increase in HIV patients under integrase inhibitor-based drug treatments.


The  Integrase Strand Transfer Inhibitor (INSTI) antiretrovirals are  among the last generation drugs to treat HIV-infected patients. Recent data indicate that these patients show abnormally increased adiposity after treatment. Thus, the HIV infection and global obesity epidemics meet to confer to HIV patients increased metabolic and cardiovascular comorbidities.The coordinated research projects  will assess the molecular and cellular basis of such phenomenon and will identify potential targets of preventive intervention.


Author tamweb
04
May
Date 04/05/2020
Categories Uncategorized

Our research group publishes the discovery of a new mechanism for regulating the metabolism of brown adipose tissue through the hormonal system kallikrein-kinin system in Nature Communications.


That system, in which bradykinin is a main actor, has been traditionally associated with the physiology of the renal and cardiovascular systems and processes of inflammation and pain. Our study, led by Dr.M.Peyrou, Juan de la Cierva researcher at our lab, reports that the kallikrein-kinin system acts as mechanism of molecular self-control of brown and beige adipose tissue thermogenic activation, and could help prevent the harmful effects of excessive activation of brown adipose tissue occurring in some pathological conditions such as cachexia or recovery from severe burns.The full article is accessible at:   https://rdcu.be/b3Ud4


Author tamweb
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