The development of anti-obesity drugs based on incretin agonists is revolutionizing obesity treatment. An analysis of the effects of these drugs, carried out by F. Villarroya, M. Peyrou, and M. Giralt, emphasizes the importance of adipose tissue and its plasticity in the biological response to these medications. The study has been published in Current Obesity Reports, a leading journal in establishing the state-of-the-art in obesity research.